Which country was at the center of scientific advancement in the 1400s?
In 1088, the first university opened its doors in Bologna in modern-day Italy, and others soon followed. It was in these universities that a new form of humanism, derived from ancient Greek texts, took hold. Soon, other city-states such as Venice and, especially, Florence, became intellectual and artistic powerhouses in the 15th and 16th centuries.
Source: History.com